AIM-100
- Product Name
- AIM-100
- CAS No.
- 873305-35-2
- Chemical Name
- AIM-100
- Synonyms
- AIM-100;AIM 100;AIM100;(S)-5,6-Diphenyl-N-[(2-tetrahydrofuryl)methyl]furo[2,3-d]pyrimidin-4-amine;(S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine;5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine;Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-;TMPRSS2,AIM-100,AIM 100,Inhibitor,Ack1,NKX3.1,TNK2,ATM,Activated Cdc42 kinase 1,Tyr-phosphorylation,PSA,Tyr267,inhibit,anticancer
- CBNumber
- CB72624072
- Molecular Formula
- C23H21N3O2
- Formula Weight
- 371.43
- MOL File
- 873305-35-2.mol
AIM-100 Property
- Boiling point:
- 552.9±50.0 °C(Predicted)
- Density
- 1.243±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- insoluble in H2O; ≥35.8 mg/mL in EtOH with gentle warming; ≥36 mg/mL in DMSO with gentle warming
- form
- Powder
- pka
- 4.62±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29487
- Product name
- AIM 100
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 29487
- Product name
- AIM 100
- Packaging
- 50mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 29487
- Product name
- AIM 100
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 29487
- Product name
- AIM 100
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 4946
- Product name
- AIM100
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $214
- Updated
- 2021/12/16
AIM-100 Chemical Properties,Usage,Production
Uses
AIM-100 modulates ligand-independent AR activity and inhibits prostate cell growth.
Biological Activity
aim-100 is a small inhibitor of ack1 tyrosine kinase with ic50 value of 24 nm [1].aim-100 mimicked atp and inhibited the activity of ack1 significantly and specifically. it showed no inhibition activity for the other 30 kinases including pi3-kinase and akt, and showed a five-fold higher ic50 value for lck. in mef cells treated with egf, aim-100 caused a remarkable decrease of the activation of ack1. in the human prostate cancer cells lncap and lapc4, aim-100 treatment resulted in an increase of g0/g1 cell phase and subsequent cell growth suppression. these effects of aim-100 also exerted in the pancreatic cancer cells. aim-100 induced apoptosis in panc-1 cells at concentration of 10 μm. moreover, aim-100 inhibited cell growth with gi50 values of 7 to 8 μm in cd-18, panc-1, ov90, mcf-7 and mda-mb-468 cancer cells [1, 2].
storage
Store at +4°C
References
1. mahajan k, challa s, coppola d, et al. effect of ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. the prostate, 2010, 70(12): 1274-1285. 2. mahajan k, coppola d, chen y, et al. ack1 tyrosine kinase activation correlates with pancreatic cancer progression. the american journal of pathology, 2012, 180(4): 1386-1393.